P-graph

Research performed at the Center for Advanced Process Optimization is mainly concerned with a class of integer and mixed integer programming problems pertaining to process systems engineering, e.g., process synthesis and scheduling, which is highly complex mathematically. One of the major contributions of the Center has been the solution of unsolved theoretical problems of process synthesis that has also been verified in practice. Process synthesis is an inventive step; in fact, it is one of the earliest actions to be taken by the process designer to create the structure, network or flowsheet of a process, satisfying the given requirements in terms of constraints and specifications and attaining the prescribed objectives. Naturally, the process designer or synthesizer is always hopeful that any resultant process network or flowsheet is not only technically feasible but also optimal in the light of the objectives, goals or end-uses. Frequently, the major objective in the processing industry is to manufacture the least-cost products or the products yielding the maximum profit. Moreover, this must be accomplished by satisfying all specifications and meeting all constraints, which can be technical, societal, environmental, and/or legal. In spite of the importance of process synthesis and the numerous methods proposed for it, many of the fundamental theoretical problems in each phase of process synthesis remain unsolved. Thus, the validity or quality of the solution of an industrial-scale synthesis problem obtained by any available method is highly questionable.

Research partners

University of Pannónia, Veszprém	Green Source Holding LLC, Austin, USA	Budapest University of Technology and Economics, Hungary	University of Szeged, Hungary
Pázmány Péter Catholic University, Hungary	University of Nottingham, Malaysia	Graz University of Technology, Austria	Autonomous University of Bucaramanga, Columbia
Chemical Engineering at National Cheg Kung University, Taiwan	De La Salle University, Manila, Philippines	De La Salle University, Manila, Philippines	Kansas State University, Manhattan, Kansas, U.S.A.
The University of Manchester Institute of Science and Technology, Manchester, United Kingdom	Universitat Politecnica de Catalunya, Barcelona, Spain

Process Network Synthesis (PNS) 1991-
Separation Network Synthesis (SNS) 1993-
Waste Treatment 1994-
Structural Controllability 1995-
Reaction Pathway Identification (RPI) 1997-
Scheduling1999-
Process Network Synthesis with Heat Integration (PNS+HENS) 1999-
Azeotropic Distillation (AD) 2000-
Structural Startability 2003-
Synthesis of Reliability Process Networks 2008-
Process Network Synthesis with Time Constraints (TCPNS) 2010-

Preventive Environmental Protection Approaches in Europe, 1993-95, Technical University of Graz, Austria (PREPARE Program)
Theoretical Foundation of Process Synthesis, 1994-95, Research Fund of the Hungarian Ministry of Education
Algorithmic Generation of the Mathematical Programming Model for Separation Network Synthesis, 1994-97, Hungarian Research Foundation (OTKA Program)
Process Integration with Combined Heat and Power, 1995-96, European Union (PECO Program)
Simulation Program for Biotechnology, 1995-96, National Committee for Technological Development, Hungary
Process Simulation, 1995-96, Technical University of Graz, Austria
Introduction of New Degree Courses on Environmental Oriented Chemical Process Integration, 1995-98, European Union (TEMPUS Program)
Participation in Non-Nuclear Energy "JOULED R&D", 1996-97, European Union (PHARE Program)
Combinatorial Method for the Synthesis of Industrial Systems, 1996-97, Research Fund of the Hungarian Ministry of Education
Energy and Water Use Minimization, 1996-97, National Committee for Technological Development, Hungary
Energy Conservation by Combined Heat and Power Systems, 1996-99, Hungarian-British Intergovernmental Cooperation Program
Structural Optimization of Energy Generation Systems, 1998-2000, National Committee for Technological Development, Hungary (Joining to a European Union project of the 4th RTD Framework Program on Non-Nuclear Energy)
Combinatorial Techniques for the Synthesis of Batch Chemical Processes, 1999-2002, Hungarian Research Foundation (OTKA Program)
Integrated Project Management Optimization, 2001-2003 IKTA
Knowledge management and transfer in the information society, 2002 KHVM-MEH
Online optimization of the asset traffic regarding safety requirements, 2004-2007 NKFP
Development of electronic teaching materials for engineering specialization programs, 2005-2006 HEFOP
Development of methodology for integrating logical, physical, and human security techniques by the application of intelligent agents, 2005-2008 Jedlik Ányos Program
Synthesis of biochemical reaction pathways and development of solution methods for analogous problems, 2006-2008 OTKA (Hungarian Scientific Research Fund)
Information Security R&D Center (IBKFK), 2006-2009 RET (Regional University Knowledge Center)
Minimoney micropayment system, 2007-2009 Jedlik Ányos Program
Models and algorithms for solving combinatorial problems in IT, 2010-2013 OTKA (Hungarian Scientific Research Fund)
Development of browser, search engine, and IT support for joint utilization of touristic programs and attractions close to each other in location and time, 2012-2013 GOP
Development of new type of bank “early warning” system, 2012-2014 GOP
Design of further development and optimization of energy generation and utilization systems by infocommunication technologies, 2012-2015 TÁMOP-4.2.2.A
National research center for development and market introduction of advanced infocommunication technologies, 2013-2015 TÁMOP-4.2.2.C
Development of decision support system for the cost and energy efficient management of electronics assembly plants based on state-of-the-art engineering, IT, and modeling solutions, 2015-2017 VKSZ

Vance, L., H. Cabezas, I. Heckl, B. Bertok, and F. Friedler, Synthesis of Sustainable Energy Supply Chain by the P-Graph Framework, Industrial & Engineering Chemistry Research,52(1), 266-274 (2013).

Yun, C., T. Y. Kim, T. Zhang, Y. Kim, S. Y. Lee, S. Park, F. Friedler, and B. Bertok, Determination of the Thermodynamically Dominant Metabolic Pathways, Industrial & Engineering Chemistry Research, 52(1), 222-229 (2013).

Bertok, B., K. Kalauz, Z. Sule, and F. Friedler, Combinatorial Algorithm for Synthesizing Redundant Structures to Increase Reliability of Supply Chains: Application to Biodisel Suplly, Industrial & Engineering Chemistry Research, 52(1), 181-186 (2013).

Bertok, B., M. Barany, and F. Friedler, Generating and Analyzing Mathematical Programming Models of Conceptual Process Design by P-Graph Software, Industrial & Engineering Chemistry Research, 52(1), 166-171 (2013).

Barany, M., B. Bertok, L. T. Fan, and F. Friedler, Relationship between extreme pathways and structurally minimal pathways, Bioprocess and Biosystems Engineering (in press).

Nemet, A., M. Hegyhati, J. Klemes, and F. Friedler, Increasing solar energy utilisation by rescheduling operations with heat and electricity demand, Chemical Engineering Transactions,49, 1483 - 1488 (2012).

Holczinger, T., M. Hegyhati, and F. Friedler, Simultaneous Heat Integration and Batch Process Scheduling, Chemical Engineering Transactions, 49, 337-342 (2012).

Varbanov, P. S., H. L. Lam, F. Friedler, and J. J. Klemes, Energy Generation and Carbon Footprint of Waste to Energy: Centralised vs. Distributed Processing, Computer Aided Chemical Engineering, 31 , 1402-1406 (2012).

Friedler, F. and K. M. Ng, Process systems engineering, Current Opinion in Chemical Engineering, 1(4), 418-420 (2012).

Kalauz, K., Z. Sule Z., B. Bertok, F. Friedler, and L. T. Fan, Extending process-network synthesis algorithms with time bounds for supply network design, Chemical Engineering Transactions, 29, 259-264 (2012).

Solving a separation-network synthesis problem adopting interval optimization techniques, Chemical Engineering Transactions, 29, 1525-1530 (2012).

Garcia-Ojeda, J. C., B. Bertok, F. Friedler, Planning evacuation routes with the P-Graph framework, Chemical Engineering Transactions, 29, 1531-1536 (2012).

Fan, L. T., Y.-C. Lin, S. Shafie, B. Bertok, and F. Friedler, Exhaustive Identification of Feasible Pathways of the Reaction Catalyzed by a Catalyst with Multiactive Sites via a Highly Effective Graph-Theoretic Algorithm: Application to Ethylene Hydrogenation, Industrial & Engineering Chemistry Research, 51(6), 2548-2552 (2012).

Barany, M., B. Bertok, C. Imreh, L. T. Fan, and F. Friedler, On the equivalence of direct mechanisms and structurally minimal pathways, Journal of Mathematical Chemistry, 50(5), 1347-1361 (2012).

Kettl, K. H., N. Niemetz, N. Sandor, M. Eder, I. Heckl, and M. Narodoslawsky, Regional Optimizer (RegiOpt) - Sustainable energy technology network solutions for regions, Computer-Aided Chemical Engineering, 29, 1959-1963, (2011).

Hegyhati, M. and F. Friedler, The Role of Energy Consumption in Batch Process Scheduling, Computer-Aided Chemical Engineering, 29, 1979-1983 (2011).

Bertok, B., R. Adonyi, F. Friedler, and L. T. Fan, Superstructure Approach to Batch Process Scheduling by S-graph Representation, Computer-Aided Chemical Engineering, 29, 1105-1109 (2011).

Barany, M., B. Bertok, Z. Kovacs, F. Friedler, and L. T. Fan, Solving vehicle assignment problems by process-network synthesis to minimize cost and environmental impact of transportation, Clean Technologies and Environmental Policy, 13(4), 637-642 (2011).

Hegyhati, M., T. Holczinger, A. Szoldatics, and F. Friedler, Combinatorial Approach to Address Batch Scheduling Problems with Limited Storage Time, Chemical Engineering Transactions, 25, 495-500 (2011).

Sule, Z., B. Bertok, F. Friedler, and L. T. Fan, Optimal Design of Supply Chains by P-Graph Framework Under Uncertainties, Chemical Engineering Transactions, 25, 453-458 (2011).

Varbanov, P. S., J. J. Klemes, and F. Friedler, Cell-Based Dynamic Heat Exchanger Models - Direct Determination of the Cell Number and Size, Computers & Chemical Engineering,35(5), 943-948 (2011).

Hegyháti, M. and F. Friedler, Combinatorial Algorithms of the S-Garph Framework for Batch Scheduling, Industrial & Engineering Chemistry Research, 50(9), 5169-5174 (2011).

Heckl, I., K. Kalauz, P. Kalocsai, and L. Halasz, Custom simulator for logistic networks in downstream, Clean Technology and Environmental Policy, 12, 627-634 (2010).

Smidla, J. and I. Heckl, S-graph Based Scheduling Method for Parallel Architecture, Chemical Engineering Transactions, 21, 937-942 (2010).

Varga, V., I. Heckl, F. Friedler, and L. T. Fan, PNS Solutions: A P-Graph based programming framework for process-network synthesis problems, Chemical Engineering Transactions, 21, 1387-1392 (2010).

Adonyi, R., I. Heckl, A. Szalamin, and F. Olti, Routing of railway systems with the S-graph framework, Chemical Engineering Transactions, 21, 913-918 (2010).

Sandor, N., M. Eder, N. Niemetz, K.-H. Kettl, M. Narodoslawsky, and L. Halasz, Optimizing the energy link between city and industry, Chemical Engineering Transactions, 21, 295-300 (2010).

Hegyhati, M. and F. Friedler, Overview of Industrial Batch Process Scheduling, Chemical Engineering Transactions, 21, 895-900 (2010).

Barany, M., B. Bertok, Z. Kovacs, F. Friedler, and L. T. Fan, Optimization Software for Solving Vehicle Assignment Problems to Minimize Cost and Environmental Impact of Transportation, Chemical Engineering Transactions, 21, 499-504 (2010).

Lam, H. L., J. J. Klemes, F. Friedler, Z. Kravanja, and P. S. Varbanov, Software Tools Overview: Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction, Chemical Engineering Transactions, 21, 487-492 (2010).

Halasz, L., M. Eder, N. Sandor, N. Niemetz, K. H. Kettl, H. Tomo, and M. Narodoslawsky, Optimal integration of sustainable technologies in industrial parks, Chemical Engineering Transactions, 19, 43-48 (2010).

Friedler, F., Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction, Applied Thermal Engineering, 30(16), 2270-2280 (2010).

Lainez, J. M., M. Hegyhati, F. Friedler, and L. Puigjaner, Using S-graph to address uncertainty in batch plants, Clean Technologies and Environmental Policy, 12(2), 105-115 (2010).

Heckl, I., F. Friedler, and L. T. Fan, Solution of separation network synthesis problems by the P-Graph methodology, Computers & Chemical Engineering, 34(5), 700-706 (2010).

Lin, Y.-C., L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, Graph-theoretic approach to the catalytic-pathway identification of methanol decomposition, Computers & Chemical Engineering, 34(5), 821-824 (2010).

Adonyi, R., E. Shopova, and N. Vaklieva-Bancheva, Optimal schedule of a dairy manufactory, Chem. Biochem. Eng. Q., 23 (2), 231-237 (2009).

Tomo, H., M. Eder, N. Sandor, L. Halasz, and M. Narodoslawsky, Tailor-made solutions for a local industrial centre, Chemical Engineering Transactions, 18, 511-516 (2009).

Klemes, J. and F. Friedler, Advances in process integration, energy saving and emissions reduction, Applied Thermal Engineering, 30(1), 1-5 (2010).

Lin, Y.-C., L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, Graph-theoretic Approach to the Catalytic-Pathway Identification of Methanol Decomposition, Computer Aided Chemical Engineering, 26, 1293-1298 (2009).

Fan, L. T., Y. Kim, C. Yun, S. B. Park, S. Park, B. Bertok, and F. Friedler, Design of Optimal and Near-Optimal Enterprise-Wide Supply Networks for Multiple Products in the Process Industry, Ind. Eng. Chem. Res., 48, 2003-2008 (2009).

Lin, Y.-C., L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, Generation of Light Hydrocarbons through Fischer.Tropsch Synthesis: Identification of Potentially Dominant Catalytic Pathways via the Graph.Theoretic Method and Energetic Analysis, Comput. Chem. Eng., 33, 1182-1186 (2009).

Heckl, I., F. Friedler, and L.T. Fan, Solution of separation network synthesis problems by the P-Graph methodology, Computer-Aided Chemical Engineering, 26, S641-S646 (2009).

Heckl, I., P. Kalocsai, L. Halasz, and K. Kalauz, Event driven process simulation of pipeline networks, Chemical Engineering Transactions, 18, 737-742 (2009).

Dovi, V. G., F. Friedler, D. Huisingh, and J. Klemes, Cleaner energy for sustainable future, Journal of Cleaner Production, 17, 889-895 (2009).

Hegyháti, M., T. Majozi, T. Holczinger, and F. Friedler, Practical infeasibility of cross-transfer in batch plants with complex recipes: S-graph vs MILP methods, Chemical Engineering Science, 64, 605-610, (2009).

Heckl, I., F. Friedler, and L.T. Fan, Reduced Super-structure for a Separation Network Comprising Separators effected by Different Methods of Separation, Computers Chem. Engng., 33, 687-698 (2009).

Friedler, F. and P. Varbanov, Modelling and optimisation tools for water minimisation in the food industry, Handbook of water and energy management in food processing (Eds: J. Klemes, R. Smith, and J.-K. Kim), pp. 200-220, Woodhead Publishing Limited, Cambridge, England, 2008.

Kim, Y., L. T. Fan, C. Yun, S. B. Park, S. Park, B. Bertok, and F. Friedler, Graph-Theoretic Approach to Optimal Synthesis of Supply Networks: Distribution of Gasoline from a Refinery, Computer Aided Chemical Engineering, 25, 247-252 (2008).

Varbanov, P. and F. Friedler, P-Graph methodology for cost-effective reduction of carbon emissions involving fuel cell combined cycles, Applied Thermal Engineering 28, 2020.2029 (2008).

Fan, L. T., Y-C. Lin, S. Shafie, K. L. Hohn, B. Bertok, and F. Friedler, Graph-theoretic and energetic exploration of catalytic pathways of the water-gas shift reaction, J. Chin. Inst. Chem. Eng., 39, 467-473 (2008).

Fan, L. T., T. Zhang, J. Liu, P. A. Seib, F. Friedler, and B. Bertok, Price-Targeting Through Repeated Flowsheet Re-Synthesis In Developing Novel Processing Equipment: Pervaporation, Ind. Eng. Chem. Res., 47, 1556-1561 (2008).

Lin, Y.-C., L. T. Fan, S. Shafie, K. L. Hohn, B. Bertok, and F. Friedler, Catalytic Pathways Identification for Partial Oxidation of Methanol on Copper-Zinc Catalysts: CH3OH + 1/2 O2 <-> CO2 + 2 H2, Ind. Eng. Chem. Res., 47, 2523-2527 (2008).

Adonyi, R., G. Biros, T. Holczinger, and F. Friedler, Effective scheduling of a large-scale paint production system, Journal of Cleaner Production, 16 (2), 225-232 (2008).

Narodoslawsky, M., A. Niederl, and L. Halasz, Utilising renewable resources economically - new challenges and chances for process development, Journal of Cleaner Production, 16 164-170 (2008).

Fan, L. T., T. Zhang, J. Liu, J. R. Schlup, F. Friedler, and B. Bertok, Assessment of Sustainability-Potential: Hierarchical Approach, Ind. Eng. Chem. Res., 46, 4506-4516 (2007).

Fan, L.T., Y.-C. Lin, S. Shafie, K. L. Hohn, B. Bertok, and F.Friedler, Comment on: An improved microkinetic model for the water-gas shift reaction on copper [Surf. Sci. 541 (2003) 21-30], Surf. Sci., 601, 2401-2405 (2007).

Halasz, L., G. Gwehenberger, and M. Narodoslawsky, Process Synthesis for the Sugar Sector - Computer Based Insight in Industrial Development, Computer-Aided Chemical Engineering, 24, 431-436 (2007).

Holczinger, T., T. Majozi, M. Hegyhati, and F. Friedler, An Automated Algorithm for Throughput Maximization Under Fixed Time Horizon in Multipurpose Batch Plants: S-Graph Approach, presented at the ESCAPE-17, Bucharest, Romania, May 27-30, 2007, also published in Computer-Aided Chemical Engineering, 24, 649-654.

Klemes, J., I. Bulatov, J. Koppejan, F. Friedler, and J. Hetland, Novel Energy Saving Technologies Evaluation Tool, presented at the ESCAPE-17, Bucharest, Romania, May 27-30, 2007, also published in Computer-Aided Chemical Engineering, 24, 1035-1040.

Varbanov, P., J. Klemes, and F. Friedler, Integration of Fuel Cells into Combined Power Cycles, presented at the ESCAPE-17, Bucharest, Romania, May 27-30, 2007, also published in Computer-Aided Chemical Engineering, 24, 1089-1094.

Heckl, I., Z. Kovács, F. Friedler, L. T. Fan, and J. Liu, Algorithmic Synthesis of an Optimal Separation Network Comprising Separators of Different Classes, Chemical Engineering and Processing, 46, 656-665 (2007).

Friedler, F., Effective Modeling for Process Synthesis, J. Chin. Inst. Chem. Eng., 37, 481-490 (2006).

Tick, J., Z. Kovács, and F. Friedler, Synthesis of Optimal Workflow Structure, Journal of Universal Computer Science, 12, 1385-1392 (2006).

Majozi, T. and F. Friedler, Maximization of Throughput in a Multipurpose Batch Plant Under Fixed Time Horizon: S-Graph Approach, Ind. Eng. Chem. Res., 45, 6713-6720 (2006).

Klemes, J., F. Friedler, and N. Lior, Editorial Introduction, PRES conferences: Energy efficiency and environmental protection, Energy, 31(13), 2059-2061 (2006).

Weber, C., I. Heckl, F. Friedler, F. Maréchal, and D. Favrat, Network synthesis for a district energy system: A step towards sustainability, Computer-Aided Chemical Engineering, 21, 1869-1874 (2006).

Liu, J., L. T. Fan, P. A. Seib, F. Friedler, and B. Bertok, Holistic Approach to Process Retrofitting: Application to Downstream Process for Biochemical Production of Organics, Ind. Eng. Chem. Res., 45, 4200-4207 (2006).

Fan, L. T., S. Shafie, B. Bertok, F. Friedler, D.-Y. Lee, H. Seo, S. Park, and S.-Y. Lee, Graph-Theoretic Approach for Identifying Catalitic or Metabolic Pathways, Journal of the Chinese Institute of Engineers, 28, 1021-1037 (2005).

Heckl, I., F. Friedler, and L. T. Fan, Integrated Synthesis of Optimal Separation and Heat Exchanger Networks Involving Separations Based on Various Properties, Heat Transfer Engineering, 26(5), 25-41 (2005).

Halasz, L., G. Povoden and M. Narodoslawsky, Sustainable processes synthesis for renewable resources, Resources, Conservation and Recycling, 44, 293-307 (2005).

Lee, D.-Y., L. T. Fan, S. Park, S. Y. Lee, S. Shafie, B. Bertok, and F. Friedler, Complementary Identification of Multiple Flux Distributions and Multiple Metabolic Pathways, Metab. Eng., 7, 182-200 (2005).

Klemes, J. and F. Friedler, Editorial, Recent novel developments in heat integration - total site, trigeneration, utility systems and cost-effective decarbonisation. Case studies waste thermal processing, pulp and paper and fuel cells, Applied Thermal Engineering, 25, 953 (2005).

Liu, J., L. T. Fan, P. Seib, F. Friedler, and B. Bertok, Downstream Process Synthesis for Biochemical Production of Butanol, Ethanol, and Acetone from Grains: Generation of Optimal and Near-Optimal Flowsheets with Conventional Operating Units, Biotechnol. Prog., 20, 1518 - 1527 (2004).

Illes, T. and A. B. Nagy, New and elementary proof of a sufficient optimality criteria for constrained, concave minimization problems, accepted for publication in Journal of Optimization Theory and Applications (2004).

Romero, J., L. Puigjaner, T. Holczinger, and F. Friedler, Scheduling Intermediate Storage Multipurpose Batch Plants Using the S-Graph, AIChE J., 50(2), 403-417 (2004).

Illes, T., and A. B. Nagy, Egy elegseges optimalitasi kriterium szeparabilis konkav minimalizalasi feladatra, publikaciora elfogadva, SZIGMA, 2003.

Angelelli, E., A. B. Nagy, M. G. Speranza, and Z. Tuza, The On-line Multiprocessor Scheduling Problem with Known Sum of the Tasks, Journal of Scheduling, 7, 421-428 (2004).

Adonyi, R., J. Romero, L. Puigjaner, and F. Friedler, Incorporating heat integration in batch process scheduling, Applied Thermal Engineering, 23, 1743-1762 (2003).

Holenda, B., A. Dallos, A. B. Nagy, F. Friedler, and L. T. Fan, A Combinatorial Approach for Generating Environmentally Benign Solvents and Separation Agents, published in Chemical Engineering Transactions, 3, S871-S876 (2003).

Heckl, I., Z. Kovacs, F. Friedler, and L. T. Fan, Super-structure Generation for Separation Network Synthesis Involving Different Separation Methods, Chemical Engineering Transactions, 3, S1209-S1214 (2003).

Novaki, S., B. Bertok, F. Friedler, L. T. Fan, and G. Feng, Rigorous Algorithm for Synthesizing Azeotropic-Distillation Systems, Chemical Engineering Transactions, 3, S1123-S1127 (2003).

Sarkozi, N., B. Bertok, F. Friedler, and L. T. Fan, Software Tool for Formulating and Solving Various Process-Synthesis Problems, Chemical Engineering Transactions, 3, S1203-S1208 (2003).

Feng, G., L. T. Fan, P. A. Seib, B. Bertok, L. Kalotai, and F. Friedler, A Graph-Theoretic Method for the Algorithmic Synthesis of Azeotropic-Distillation Systems, Ind. Eng. Chem. Res.,42, 3602-3611 (2003).

Romero, J., A. Espuna, F. Friedler, and L. Puigjaner, A New Framework for Batch Process Optimization Using the Flexible Recipe, Industrial and Engineering Chemistry Research, 42(2), 370-379 (2003).

Holczinger, T., J. Romero, L. Puigjaner, and F. Friedler, Scheduling of Multipurpose Batch Processes with Multiple Batches of the Products, Hung. J. Ind. Chem., 30, 305-312 (2002).

Halasz, L., A. B. Nagy, T. Ivicz, F. Friedler, L. T. Fan, Optimal Retrofit Design and Operation of the Steam-Supply System of a Chemical Complex, Applied Thermal Engineering 22, 939 -947 (2002).

Hertwig, T. A., A. Xu, A. B. Nagy, R. W. Pike, J. R. Hopper, and C. L. Yaws, A Prototype System for Economic, Environmental and Sustainable Optimization of a Chemical Complex, Clean Techn. Environ. Policy, 3, 363-370, (2002).

Fan, L. T., B. Bertok, and F. Friedler, A Graph-Theoretic Method to Identify Candidate Mechanisms for Deriving the Rate Law of a Catalytic Reaction, Computers and Chemistry, 26, 265-292 (2002).

Sanmarti, E., T. Holczinger, L. Puigjaner, and F. Friedler, Combinatorial Framework for Effective Scheduling of Multipurpose Batch Plants, AIChE Journal, 48(11), 2557-2570 (2002).

Strouvalis, A., I. Heckl, F. Friedler, and A. C. Kokossis, An Accelerated Branch and Bound Algorithm for Assignment Problems of Utility Systems, Computers Chem. Engng. 26, 617-630 (2002).

Heckl, I., Z. Kovacs, and Z. Ercsey, A matematikai szigorúság fontossága a kiindulási struktúra meghatározásakor szétválasztási hálózatok szintézise esetén (in Hungarian), Magyar Kémikusok Lapja, 56, 372-377 (2001).

Fan, L. T., B. Bertok, F. Friedler, and S. Shafie, Mechanisms of Ammonia-Synthesis Reaction Revisited with the Aid of a Novel Graph-Theoretic Method for Determining Candidate Mechanisms in Deriving the Rate Law of a Catalytic Reaction, Hungarian Journal of Industrial Chemistry, 29, 71-80 (2001).

Seo, H., D.-Y. Lee, S. Park, L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, Graph-Theoretical Identification of Pathways for Biochemical Reactions, Biotechnology Letters, 23, 1551-1557 (2001).

Bertok, B., F. Friedler, G. Feng, and L.T. Fan, Systematic Generation of the Optimal and Alternative Flowsheets for Azeotropic Distillation Systems, Computer-Aided Chemical Engineering, 9, S351-S356 (2001).

Strouvalis, A., I. Heckl, F. Friedler, and A. C. Kokossis, An Accelerated Branch and Bound Algorithm for Assignment Problems of Utility Systems, Computer-Aided Chemical Engineering, 9, S541-S546 (2001).

Suh, M.-H., F. Friedler, S. Park, and T.-Y. Lee, Retrofit Design of Chemical Processing Networks under Uncertainties: Application to Petrochemical Industry, Computer-Aided Chemical Engineering, 9, S547-S552 (2001).

Nagy, A. B., R. Adonyi, L. Halasz, F. Friedler, and L. T. Fan, Integrated Synthesis of Process and Heat Exchanger Networks: Algorithmic Approach, Applied Thermal Engineering,21(13-14), 1407-1427 (2001).

Hertwig, T. A., A. Xu, A. B. Nagy, R. W. Pike, J. R. Hopper, and C. L. Yaws, A Prototype System for Economic, Enviromental and Sustainable Optimization of a Chemical Complex, Computer-Aided Chemical Engineering, 9, S1017-S1022 (2001).

Feng, G., L. T. Fan, F. Friedler, and P. A. Seib, Identifying Operating Units for the Design and Synthesis of Azeotropic-Distillation Systems, Ind. Eng. Chem. Res., 39, 175-184 (2000).

Kovacs, Z., Z. Ercsey, F. Friedler, and L. T. Fan, Separation-Network Synthesis: Global Optimum through Rigorous Super-Structure, Computers Chem. Engng, 24, 1881-1900 (2000).

Brendel, M. H., F. Friedler, and L. T. Fan, Combinatorial Foundation for Logical Formulation in Process Network Synthesis, Computers Chem. Engng, 24, 1859-1864 (2000).

Klemes, J. and F. Friedler, Editorial, Applied Thermal Engineering, 20, 1335 (2000).

Strouvalis, A. M., I. Heckl, F. Friedler, and A. C. Kokossis, Customized Solvers for the Operational Planning and Scheduling of Utility Systems, Computers Chem. Engng, 24, 487-493 (2000).

Friedler, F. and J. Klemes, Editorial, Waste Management, 20, vii (2000).

Feng, G., L. T. Fan, and F. Friedler, Synthesizing Alternative Sequences via a P-Graph-Based Approach in Azeotropic Distillation Systems, Waste Management, 20, 639-643 (2000).

Halasz, L., and K. Rajnai, Nitrocellulózüzem víz- és energiafelhasználásának minimalizálása kombinatorikus módszerrel (in Hungarian), Magyar Kémikusok Lapja, 55, 134-141 (2000).

Imreh, B., J. Fulop, and F. Friedler, A Note on the Equivalence of the Set Covering and Process Network Synthesis Problems, Acta Cybernetica, 14, 497-501 (2000).

Kovacs, Z., Z. Ercsey, F. Friedler, and L. T. Fan, Exact Super-Structure for the Synthesis of Separation-Networks with Multiple Feed-Streams and Sharp Separators, Computers Chem. Engng, 23, S1007-1010 (1999).

Kalotai L., Dallos A., Friedler F., L. T. Fan, Kombinatorikus modszer kivant tulajdonsagu molekulak tervezesehez (in Hungarian), Magyar Kemikusok Lapja, 54, 173-181 (1999).

Kovacs, Z., Z. Ercsey, F. Friedler, and L. T. Fan, Redundancy in a Separation-Network, Hungarian Journal of Industrial Chemistry, 26, 213-219 (1998).

Fulop, J., B. Imreh, and F. Friedler, On the Reformulation of Some Classes of PNS-Problems as Set Covering Problems, Acta Cybernetica, 13, 329-337 (1998).

Sanmarti, E., F. Friedler, and L. Puigjaner, Combinatorial Technique for Short Term Scheduling of Multipurpose Batch Plants Based on Schedule-Graph Representation, Computers Chem. Engng, 22, S847-850 (1998).

Friedler, F., L. T. Fan, L. Kalotai, and A. Dallos, A Combinatorial Approach for Generating Candidate Molecules with Desired Properties Based on Group Contribution, Computers Chem. Engng, 22, 809-817 (1998).

Friedler, F., L. T. Fan, and B. Imreh, Process Network Synthesis: Problem Definition, Networks, 28, 119-124 (1998).

Friedler, F., J. B. Varga, and L. T. Fan, Decision-Mapping: A Tool for Consistent and Complete Decisions in Process Synthesis, Chem. Engng Sci., 50, 1755-1768 (1995).

Varga, J. B., F. Friedler, and L. T. Fan, Parallelization of the Accelerated Branch-and-Bound Algorithm of Process Synthesis: Application in Total Flowsheet Synthesis, Acta Chimica Slovenica, 42, 15-20 (1995).

Hangos, K. M., J. B. Varga, F. Friedler, and L. T. Fan, Integrated Synthesis of a Process and Its Fault-Tolerant Control System, Computers Chem. Engng, 19, S465-470 (1995).

Kovacs, Z., F. Friedler, and L. T. Fan, Parametric Study of Separation Network Synthesis: Extreme Properties of Optimal Structures, Computers Chem. Engng, 19, S107-112 (1995).

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Graph-Theoretic Approach to Process Synthesis: Polynomial Algorithm for Maximal Structure Generation, Computers Chem. Engng,17, 929-942 (1993).

Kovacs, Z., F. Friedler, and L. T. Fan, Recycling in a Separation Process Structure, AIChE J., 39, 1087-1089 (1993).

M. Narodoslawsky, F. Friedler, L. Kiraly, and H. J. Altenburger, SIMBIOS - A New Simulation Program for Biotechnology with Novel Design, Chem. Biochem. Eng. Q., 7, 27-30 (1993).

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Graph-Theoretic Approach to Process Synthesis: Axioms and Theorems, Chem. Engng Sci., 47, 1973-1988 (1992).

Jezowski, J. and F. Friedler, A Simple Approach for Maximum Heat Recovery Calculations, Chem. Engng Sci., 47, 1481-1494 (1992).

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Combinatorial Algorithms for Process Synthesis, Computers Chem. Engng, 16, S313-320 (1992).

Jezowski, J. and F. Friedler, A Note on Targeting in the Design of Cost Optimal Heat Exchanger Networks, Chem. Biochem. Eng. Q., 5, 1-9 (1991).

Plant Design and Economics for Chemical Engineers

State of the Art in Global Optimization: Computational Methods and Applications

Vance, L., I. Heckl, B. Bertok, H. Cabezas, and F. Friedler, Sustainable Design of Energy Supply Chains from P-Graphs: Cost, Ecological Footprint, and Emergy, AIChE Annual Meeting, Pittsburgh, PA, U.S.A., October 28 . November 2, 2012.

Solving a separation-network synthesis problem adopting interval optimization techniques, presented at the PRES 2012, Praha, Czech Republic, August 25-29, 2012.

Garcia-Ojeda, J. C., B. Bertok, F. Friedler, Planning evacuation routes with the P-graph framework, presented at the PRES 2012, Praha, Czech Republic, August 25-29, 2012.

Kalauz, K., Z. Sule, B. Bertok, F. Friedler, L. T. Fan, Extending process-network synthesis algorithms with time bounds for supply network design, presented at the PRES 2012, Praha, Czech Republic, August 25-29, 2012.

Nemet, A., M. Hegyhati, J. Klemes, and F. Friedler, Increasing solar energy utilization by rescheduling operations with heat and electricity demand, SDEWES 2012 (7th Conference on Sustainable Development of Energy, Water and Environment Systems), Ohrid, Republic of Macedonia, July 1-7, 2012.

Adonyi, R., I. Heckl, and F. Olti, Construction project scheduling by P-graphs, presented at Factory Automatization Conference 2012, Veszprém, Hungary, May 21-22, 2012.

Kalauz, K., I. Heckl, P. I. Borbas, B. Bertok, and L. Halasz, Downstream Supply Chain Simulator and Planner, presented at Factory Automatization Conference 2012, Veszprém, Hungary, May 21-22, 2012.

Tarczali, T., T. Kiezer, Z. Sule, I. Heckl, and T. Varjas, Quality assurance of assembling storage systems by automatic generation of test sequences, presented at Factory Automatization Conference 2012, Veszprém, Hungary, May 21-22, 2012.

Heckl, I., R. Adonyi, B. Bertok, and A. Szlama, Scheduling of the transport of renewables for a power plant, presented at Factory Automatization Conference 2012, Veszprém, Hungary, May 21-22, 2012.

Hegyhati, M. and F. Friedler, Tools of Discrete Event Systems for Batch Process Scheduling, presented at CAPE forum 2012, Veszprém, Hungary, March 26-28, 2012.

Heckl, I., H. Cabezas, F. Friedler, and L. T. Fan, Sustainable Supply Chain Design by the P-Garph Framework, AIChE Annual Meeting, Minneapolis, MN, U.S.A., October 16-21, 2011.

Hegyhati, M., T. Holczinger, and F. Friedler, In-Depth Study and Comparison of S-Graph Framework and Precedence Based MILP Formulations for Batch Process Scheduling, AIChE Annual Meeting, Minneapolis, MN, U.S.A., October 16-21, 2011.

Bertok, B., R. Adonyi, F. Friedler, and L. T. Fan, Superstructure Approach to Batch Process Scheduling by S-graph Representation, presented at the ESCAPE 21 (21st European Symposium on Computer Aided Process Engineering), Chalkidiki, Greece, May 29 - June 1, 2011.

Hegyhati, M. and F. Friedler, The Role of Energy Consumption in Batch Process Scheduling, Bertok, B., R. Adonyi, F. Friedler, and L. T. Fan, Superstructure Approach to Batch Process Scheduling by S-graph Representation, presented at the ESCAPE 21 (21st European Symposium on Computer Aided Process Engineering), Chalkidiki, Greece, May 29 - June 1, 2011.

Hegyhati, M., T. Holczinger, A. Szoldatics, and F. Friedler, Combinatorial Approach to Address Batch Scheduling Problems with Limited Storage Time, presented at the PRES'11 (14th International Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Florence, Italy, May 8-11, 2011.

Sule, Z., B. Bertok, F. Friedler, and L. T. Fan, Optimal Design of Supply Chains by P-graph Framework Under Uncertainties, presented at the PRES 2011, Florence, Italy, May 8-11, 2011.

Varbanov, P. S. and F. Friedler, P-graph methodology for cost-effective reduction of carbon emissions involving fuel cell combined cycles, presented at the ICMSAO 2011 (International Conference on Modeling, Simulation and Applied Optimization), Kuala Lumpur, Malaysia, April, 19-21, 2011, also published in the Proceedings of the Conference, DOI: 10.1109/ICMSAO.2011.5775477.

Friedler, F., Supply Chain Management Sustainability and Profitability, presented at the ICOSSE'11 (International Congress on Sustainability Science and Engineering), Tucson, AZ, U.S.A., January 9-12, 2011.

Adonyi, R., I. Heckl, and F. Olti, Scheduling of Bus Maintenance by the P- graph Methodology, presented at the VOCAL 2010 (Veszprém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 13-15, 2010.

Kalauz, K., Z. Süle, B. Bertok, F. Friedler, and L. T. Fan, Generation of Redundant Structures to Guarantee Predefined Level of Reliability in Business Processes, presented at the VOCAL 2010 (Veszprém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 13-15, 2010.

Bertok, B., K. Kalauz, Z. Süle, L. T. Fan, and F. Friedler, Algorithmic Synthesis of Process Networks wit Time Constraints by the P-garph Framework, presented at the VOCAL 2010 (Veszprém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 13-15, 2010.

Holczinger, T., M. Hegyháti, and F. Friedler, S-graph as an integrated modeling and optimization tool for the scheduling of industrial batch processes, presented at the VOCAL 2010 (Veszprém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 13-15, 2010.

Varbanov, P., J. Klemes, and F. Friedler, Cell-based dynamic heat exchanger models - direct determination of the cell number and size, presented at the VOCAL 2010 (Veszprém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 13-15, 2010.

Halasz, L., M. Eder, N. Sandor, N. Niemetz, K. H. Kettl, and M. Narodoslawsky, Using P-Graph for Optimising Regional Sustainable Energy Systems, presented at the VOCAL 2010 (Veszprém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 13-15, 2010.

Tarczali, T., H. Kadanoczki, E. Osz, G. Zachar, K. Kalauz, and Z. Sule, P-graph Representation and Structural Analysis of Business Process Models, presented at the VOCAL 2010 (Veszprém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 13-15, 2010.

Halasz, L., M. Eder, N. Sandor, N. Niemetz, K.-H. Kettl, and M. Narodoslawsky, Optimizing the energy link between city and industry, presented at the PRES 2010 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 28-September 1, 2010.

Smidla, J. and I. Heckl, S-graph Based Scheduling Method for Parallel Architecture, presented at the PRES 2010 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 28-September 1, 2010.

Varga, V., I. Heckl, F. Friedler, and L. T. Fan, PNS Solutions: A P-graph based programming framework for process-network synthesis problems, presented at the PRES 2010 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 28-September 1, 2010.

Adonyi, R., I. Heckl, A. Szalamin, and F. Olti, Routing of railway systems with the S-graph framework, presented at the PRES 2010 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 28-September 1, 2010.

Hegyhati, M. and F. Friedler, Overview of industrial batch process scheduling, presented at the PRES 2010 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 28-September 1, 2010.

Hegyhati, M., J. M. Lainez, L. Puigjaner, and F. Friedler, Preemptive optimization of chemical batch processes with continuous external uncertainties based on a novel S-graph branching strategy, presented at the PRES 2010 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 28-September 1, 2010.

Adonyi, R., E. G. Kirilova, and N. Vaklieva-Bancheva, Systematic approach for scheduling supply chain activities, presented at the PRES 2010 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 28-September 1, 2010.

Barany, M., B. Bertok, Z. Kovacs, and F. Friedler, Optimization software for solving vehicle assignment problems to minimize cost and environmental impact of transportation, presented at the PRES 2010 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 28-September 1, 2010.

Kalauz, K., Z. Sule, B. Bertok, F. Friedler, and L. T. Fan, Reliability Analysis of Business Processes via the P-graph Framework, presented at International Conference on Computational Management Science, Vienna, Austria, July 28-30, 2010.

Kalauz, K. and B. Bertok, Algorithmic Synthesis of Structural Alternatives for Business Processes, presented at The 7th Conference of PhD Students in computer Science, Szeged, Hungary, June 29-July 2, 2010.

Klemes, J., H. L. Lam, P. Varbanov, and F. Friedler, Biomass energy generation, carbon footprint minimization and supply chain synthesis, 37th International Conference of SSCHE (Slovak Society of Chemical Engineering), Tatranske Matliare, Slovak Republic, May 24-28, 2010.

Heckl, I., F. Friedler, and L.T. Fan, Solution of separation network synthesis problems by the P-graph methodology, presented at ESCAPE 19 (19th European Symposium on Computer Aided Process Engineering), Cracow, Poland, June 14-17, 2009.

Lin, Y. C., L. T. Fan, S. Shafie, F. Friedler, and B. Bertok, Catalytic Pathways Identification for Partial Oxidation of Methanol on Copper-zinc Catalysts, presented at ESCAPE 19 (The 19th European Symposium on Computer Aided Process Engineering), Cracow, Poland, June 14-17, 2009.

Bertok, B., R. Adonyi, F. Friedler, and L. T. Fan, Optimal Design of Supply Chains by the P-graph Framework, presented at ESCAPE 19 (The 19th European Symposium on Computer Aided Process Engineering), Cracow, Poland, June 14-17, 2009.

Kalauz, K., Z. Sule, T. Tarczali, B. Bertók, and F. Friedler, P-gráf módszertan alkalmazása biztonságos üzleti folyamatok modellezésére, presented at the XXVIII: Magyar Operációkutatási Konferencia, Balatonoszöd, 2009.

Heckl, I., P. Kalocsai, L. Halasz, and K. Kalauz, Event driven process simulation of pipeline networks, presented at PRES'09 (12th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Rome, Italy, May 10-13, 2009.

Nagy, A., N. Kovacs, T. Tarczali, and Z. Sule, Generating Test Charts for Adaptive Quality Assurance of Manufacturing Low Volume High Value Products, presented at the Veszprém Optimization Conference: Advanced Algorithms (VOCAL), 2008.

Heckl, I., R. Adonyi, B. Bertok, F. Friedler, L.T. Fan, and Z. Kovacs, Formulating and Solving Vehicle Routing Problems by the P-graph Framework, presented at the VOCAL 2008 (3rd Veszprém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 15-17, 2008.

Adonyi, R., K. Kalauz, B. Bertok, L. T. Fan, and F. Friedler, Conceptual Design of Business Processes by Process-Network Synthesis, presented at the VOCAL 2008 (Veszpém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 15-17, 2008.

Bertok, B., K. Kalauz, F. Friedler, and L. T. Fan, Reaction-Pathway Identification: Models and Algorithms, presented at the VOCAL 2008 (Veszpém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 15-17, 2008.

Hegyhati, M., T. Majozi, T. Holczinger, F. Friedler, Practical Feasibility of Mathematical Models in Scheduling, presented at the VOCAL 2008 (Veszpém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 15-17, 2008.

Sule, Z., B. Bertok, and F. Friedler, Combinatorial Approach to the Optimal Design of Security Systems, presented at the VOCAL 2008 (Veszpém Optimization Conference: Advanced Algorithms), Veszprém, Hungary, December 15-17, 2008.

Lin, Y.-C., L. T. Fan, S. R. Shafie, B. Bertok, and F. Friedler, Catalytic-Pathway Identification for Methanol Decomposition on Pt (1 1 1) Via the Graph-Theoretic Method Based on P-Graphs, AIChE Annual Meeting, Philadelphia, PA, U.S.A., November 15-21, 2008.

Fan, L. T., T. Zhang, A. Argoti, J. Liu, B. Bertok, and F. Friedler, Graph-Theoretic Approach for Discovering Alternative Synthetic Routes Forming Complex Networks, AIChE Annual Meeting, Philadelphia, PA, U.S.A., November 15-21, 2008.

Bertok, B., K. Kalauz, F. Friedler, Y.-C. Lin, L. T. Fan, and S. Shafie, Combinatorially accelerated branch-and-bound method for identifying potentially dominant catalytic pathways, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Adonyi, R., B. Bertok, and F. Friedler, Optimization of distribution networks, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Kalauz, K., B. Bertok, L. T. Fan, and F. Friedler, Reaction-pathway identification: methods and software, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Heckl, I., F. Friedler, and L. T. Fan, Separation network synthesis: reduced superstructure for a network involving different methods of separation, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Tar, P., F. Friedler, and L. T. Fan, Effective algorithms for process-network synthesis, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Hegyhati, M., T. Majozi, F. Friedler, Throughput maximization in a multipurpose batch plant, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Laínez, J. M., M. Hegyhati, L. Puigjaner, and F. Friedler, Using S-graph to address uncertainty in batch plants, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Majozi, T., T. Holczinger, and F. Friedler, Implications of cross-transfer in batch plants with complex recipes: S-graph vs MILP methods, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Holczinger, T., T. Majozi, and F. Friedler, Optimal scheduling of batch plants with complex recipes, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Halasz, L., G. Gwehenberger, F. Friedler, and M. Narodoslawsky, Designing local sustainable industrial centres, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Friedler, F. and P. Varbanov, Energy infrastructures for integrating renewables and fossil fuels for improved energy supply chains, presented at the PRES 2008 (11th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 24-28, 2008.

Friedler, F., P. Varbanov, and J. Klemes, Integration of fuel cells into combined power cycles, presented at the IFORS 2008 (International Federation of Operational Research Societies Conference), Sandton, South-Africa, July 13-18, 2008.

Friedler, F. and L. T. Fan, Optimization of industrial plants and production: p-graph and s-graph methodologies, presented at the IFORS 2008 (International Federation of Operational Research Societies Conference), Sandton, South-Africa, July 13-18, 2008.

Majozi, T., F. Friedler, T. Holczinger, and M. Hegyhati, S-graph based continuous-time approach for throughput maximization in multipurpose batch plants, presented at the IFORS 2008 (International Federation of Operational Research Societies Conference), Sandton, South-Africa, July 13-18, 2008.

Bertok, B., F. Friedler, and J. Klemes, P-graph Framework: An Alternative to MILP for Formulating and Solving Management Decision Support Problems, presented at the CMS 2008 (5th International Conference on Computational Management Science), London, March 26-28, 2008.

Fan, L. T., T. Zhang, J. Liu, P. A. Seib, F. Friedler, and B. Bertok, Price-Targeting Through Repeated Flowsheet Re-Synthesis In Developing Novel Processing Equipment, presented at the AIChE Annual Meeting, Salt Lake City, Utah, U.S.A., November 4-9, 2007.

Bertok, B., R. Adonyi, Z. Kovacs, and F. Friedler, Algorithmic Synthesis of Supply Chains, presented at the XIX Polish Conference of Chemical and Process Engineering, Rzeszow, Poland, September 3-7, 2007.

Kalauz, K., B. Bertok, F. Friedler, and L. T. Fan, Systematic Methods for Reaction-Pathway Identification, presented at the XIX Polish Conference of Chemical and Process Engineering, Rzeszow, Poland, September 3-7, 2007.

Hegyhati, M., T. Holczinger, T. Majozi, and F. Friedler, Transforming STN based scheduling problems to S-graph representation, presented at the XIX Polish Conference of Chemical and Process Engineering, Rzeszów, Poland, September 3-7, 2007.

Adonyi, R., T. Holczinger, T. Majozi, and F. Friedler, Novel branching procedure for S-graphs based scheduling of batch processes, presented at the XIX Polish Conference of Chemical and Process Engineering, Rzeszów, Poland, September 3-7, 2007.

Holczinger, T., T. Majozi, M. Hegyhati, and F. Friedler, Throughput Maximization in Multipurpose Batch Plants: S-graph vs. Time Point Based Methods, presented at the PRES'07, ISCHIA Island Gulf of Naples, Italy, June 24-27, 2007.

Kalauz, K., B. Bertók, F. Friedler, and L. T. Fan, Sztöchiometriai egyenletrendszerek minimális számú aktív változót tartalmazó megoldásainak generálása a P-gráf módszertan alkalmazásával, XXVII. MAGYAR OPERÁCIÓKUTATÁSI KONFERENCIA, Balatonöszöd, Hungary, June 7-9, 2007.

Halasz, L., G. Gwehenberger, and M. Narodoslawsky, Process Synthesis for the Sugar Sector - Computer Based Insight in Industrial Development, presented at the ESCAPE-17, Bucharest, Romania, May 27-30, 2007.

Bertok, B., R. Adonyi, S. Bodrogi, and Z. Kovacs, Optimization Problems and Algorithms in Supply-Chain Management, presented at the Veszprém Optimization Conference: Advanced Algorithms (VOCAL), Veszprem, Hungary, December 13-15, 2006.

Bertok, B., K. Kalauz, and L. T. Fan, Exhaustively Generating Basis Solutions for a System of Stoichiometrically Balanced Elementary Reactions by Resorting to the P-graph-based Method, presented at the Veszprém Optimization Conference: Advanced Algorithms (VOCAL), Veszprem, Hungary, December 13-15, 2006.

Holczinger, T., T. Majozi, M. Hegyhati, and F. Friedler, Using S-graph Approach for Throughput Maximization in Multipurpose Batch Plants, presented at the VOCAL 2006, Veszprém, Hungary, December 13-15, 2006.

Fan, L.T., T. Zhang, J. Liu, P. A. Seib, S. T. Chou, F. Friedler, and B. Bertok, Sustainable Production of Gasohol from Biomass, presented at the AIChE 2006 Annual Meeting, San Francisco, CA, U.S.A., November 12-17, 2006.

Fan, L.T., Y.-C. Lin, S. Shafie, K. L. Hohn, B. Bertok, and F. Friedler, Microkinetic Model for the Water-gas Shift Reaction on Supported Copper Catalyst, presented at the AIChE 2006 Annual Meeting, San Francisco, CA, U.S.A., November 12-17, 2006.

Lin, Y.-C., L. T. Fan, S. Shafie, K. L. Hohn, B. Bertok, and F. Friedler, Exhaustive Identification of Stoichiometrically Feasible Pathways of Partial Oxidation of Methanol on Copper-Zinc Catalysts, presented at the AIChE 2006 Annual Meeting, San Francisco, CA, U.S.A., November 12-17, 2006.

Bertok, B., F. Friedler, J. Liu, L. T. Fan, and P. A. Seib, Evaluating new technologies by process synthesis: Illustration with Biochemical Production of Butanol, Ethanol, and Acetone, presented at the PRES 2006, Praha, Czech Republic, August 27-31, 2006.

Nagy, Z., B. Bertok, F. Friedler, D.-Y. Lee, L. T. Fan, and S. Shafie, Exploring Mechanisms Leading to Robust Biochemical Systems, presented at the PRES 2006, Praha, Czech Republic, August 27-31, 2006.

Kalauz, K., B. Bertok, F. Friedler, and L. T. Fan, Reaction pathway identification: relations of methods based on graph theory and linear algebra, presented at the CHISA 2006 (17th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 27-31, 2006.

Majozi, T., T. Holczinger, R. Adonyi, F. Friedler, Maximization of throughput over a fixed time horizon using a recently developed S-graph approach: A pharmaceuticals case study, presented at the PRES 2006, Praha, Czech Republic, August 27-31, 2006.

Adonyi, R., E. Shopova, F. Friedler, N. Vaklieva-Bancheva, Optimal schedule of a dairy manufactory, presented at the PRES 2006, Praha, Czech Republic, August 27-31, 2006.

Hegyhati, M., R. Adonyi, T. Holczinger, F. Friedler, Demonstration program for S-graph based batch-process scheduling, presented at the PRES 2006, Praha, Czech Republic, August 27-31, 2006.

Halasz, L., C. Zachhuber, M. Narodoslawsky, Beyond processes - application of process synthesis to optimising regional economies, presented at the PRES 2006, Praha, Czech Republic, August 27-31, 2006.

Nadal, S. F., T. Holczinger, C. A. Mendez, F. Friedler, and L. Puigjaner, Rigorous scheduling resolution of complex multipurpose batch plants: S-graph vs. MILP, presented at the ESCAPE-16, Garmisch-Partenkirchen, Germany, July 9-13, 2006.

Weber, C., I. Heckl, F. Friedler, F. Maréchal, and D. Favrat, Network synthesis for a district energy system: A step towards sustainability, presented at the ESCAPE-16 (16th European Symposium on Computer Aided Process Engineering), Garmisch-Partenkirchen, Germany, July 9-13, 2006.

Liu, J., L. T. Fan, P. A. Seib, F. Friedler, and B. Bertok, Feasible and Optimal Flowsheets for Downstream Processing in Biochemical Production of Butanol, Ethanol and Acetone: Inclusion of Adsorption, presented at the AIChE Annual Meeting, Cincinnati, OH, U.S.A., November 2-4, 2005.

Fan, L. T., T. Zhang, J. Liu, J. R. Schlup, F. Friedler, B. Bertok, Assessment of Sustainability-Potential: Hierarchical Approach, presented at the AIChE Annual Meeting, Cincinnati, OH, U.S.A., November 2-4, 2005.

Shafie, S. R., L. T. Fan, B. Bertok, F. Friedler, D.-Y. Lee, S. Park, and S. Y. Lee., Identification of Catalytic or Metabolic Pathways: a Graph-Theoretic Approach, presented at the AIChE Annual Meeting, Cincinnati, OH, U.S.A., November 2-4, 2005.

Friedler, F., B. Bertok, L. T. Fan, and S. Shafie, Graph-Theoretic Method for Determining Candidate Mechanisms of Catalytic Chemical and Biochemical Reactions and Its Applications, presented at the 7th World Congress of Chemical Engineering, Glasgow, Scottland, July 10-14, 2005.

Bertok, B., F. Friedler, D.-Y. Lee, L. T. Fan, S. Shafie, S. Y. Lee, and S. Park, A Novel Algorithmic Approach for Complementarily Identifying of Multiple Flux Distributions and Multiple Metabolic Pathways, presented at the Workshop "Metabolic Pathway Analysis, Jena, Germany, March 3-4, 2005.

Bertok, B., F. Friedler, L. T. Fan, and S. Shafie, Integrated Application of the Graph-Theoretic and Linear-Programming Algorithms for Identification of Feasible Candidate Mechanisms of a Catalytic Reaction, presented at the AIChE Annual Meeting, Austin, TX, U.S.A., November 7-12, 2004.

Fan, L. T., S. Shafie, B. Bertok, and F. Friedler, Reaction Pathways Identification of Catalytic Ethane Pyrolysis and Synthesis by a Graph-Theoretic Method, presented at the AIChE Annual Meeting, Austin, TX, U.S.A., November 7-12, 2004.

Novaki, S., B. Bertok, F. Friedler, and L. T. Fan, Automated Synthesis of Flowsheets for Azeotropic-Distillation Systems: Two Case Studies, presented at the PRES 2004, Praha, Czech Republic, August 22-26, 2004.

Halasz, L., A. Niederl, and M. Narodoslawsky, Process synthesis as a means for technology development, presented at the PRES 2004, Praha, Czech Republic, August 22-26, 2004.

Narodoslawsky, M., A. Niederl, and L. Halasz, Utilising renewable resources economically - new challenges and chances for process development, presented at the PRES 2004, Praha, Czech Republic, August 22-26, 2004.

Adonyi, R., G. Biros, and F. Friedler, Effective Scheduling of a Large-Scale Paint Production System, presented at the PRES 2004 (7th Conference on Process Integration, Modelling and Optimization for Energy Saving and Pollution Reduction), Prague, Czech Republic, August 22-26, 2004.

Holczinger, T., G. Biros, F. Friedler, and N. Sarkozi, Acceleration tools for batch process scheduling, presented at the CHISA 2004 (16th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 22-26, 2004.

Bertok, B., S. Novaki, F. Friedler, and L. T. Fan, Algorithmic Flowsheet Generation for Synthesizing Azeotropic-Distillation Systems, presented at the PRES 2003, Hamilton, Ontario, Canada, October 26-29, 2003.

Liu, J., L. T. Fan, P. Seib, F. Friedler, and B. Bertok, Optimal and Near-Optimal Flowsheets for Downstream Processing in Biochemical Production of Butanol, Ethanol, and Acetone: Synthesis with Conventional Operating Units, presented at the PRES 2003, Hamilton, Ontario, Canada, October 26-29, 2003.

Heckl, I., F. Friedler, and L. T. Fan, Algorithmic Synthesis of Optimal Heat Integrated Separation Networks, presented at the PRES 2003 (6th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Hamilton, Ontario, Canada, October 26-29, 2003.

Biros, G., F. Friedler, J. Romero, and L. Puigjaner, Multi-Objective Optimization in Batch Process Scheduling, presented at the 53rd Canadian Chemical Engineering (CSChE2003/PRES 2003) Conference in Hamilton, Ontario, Canada October 26-29, 2003.

Adonyi, R., J. Romero, L. Puigjaner, and F. Friedler, Heat Integration for Batch Processes presented at the PRES 2003, Hamilton, Ontario, Canada, October 26-29, 2003.

Halasz, L., G. Povoden, and M. Narodoslawsky, Process Synthesis for Renewable Resources presented at the PRES 2003, Hamilton, Ontario, Canada, October 26-29, 2003.

Friedler, F., and L. T. Fan, Process Design and Operation: Decomposition vs. Integration, presented at the PRES 2003, Hamilton, Ontario, Canada, October 26-29, 2003.

Angelelli, E., A. B. Nagy, M. G. Speranza, Zs Tuza, The on-line multiprocessor scheduling problem with known sum of the tasks AIRO 2003 (XXXIV Annual Conference of the Italian Operations Research Society), Venezia, Italy, September 2-5, 2003.

Fan, L. T., S. Shafie, S. Khaitan, A. More, B. Bertok, and F. Friedler, Algorithmic Identification of Mechanisms of the Ethylene Hydrogenation Reaction, presented at the AIChE Annual Meeting, San Francisco, CA, U.S.A., November 16-21, 2003.

Lee, D.-Y., L. T. Fan, S. Park, S. Y. Lee, S. Shafie, B. Bertok, and F. Friedler, Synergistic Identification of Multiple Flux Distributions and Multiple Metabolic Pathways, presented at the AIChE Annual Meeting, San Francisco, CA, U.S.A., November 16-21, 2003.

Liu, J., L. T. Fan, P. Seib, F. Friedler, and B. Bertok, Feasible and Optimal Flowsheets for Downstream Processing in Biochemical Production of Butanol, Ethanol, and Acetone: Inclusion of Pervaporation, presented at the AIChE Annual Meeting, San Francisco, CA, U.S.A., November 16-21, 2003.

Heckl, I., Z. Kovacs, F. Friedler, and L. T. Fan, Super-Structure Generation for Separation-Network Synthesis Involving Different Separation Methods, presented at the ICheaP-6 (6th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Pisa, Italy, June 8-11, 2003.

Novaki, S., B. Bertok, F. Friedler, L. T. Fan, and G. Feng, Rigorous Algorithm for Synthesizing Azeotropic-Distillation Systems, presented at the ICheaP-6, Pisa, Italy, June 8-11, 2003.

Sarkozi, N., B. Bertok, F. Friedler, and L. T. Fan, Software Tool for Formulating and Solving Various Process-Synthesis Problems, presented at the ICheaP-6, Pisa, Italy, June 8-11, 2003.

Holenda, B., A. B. Nagy, A. Dallos, F. Friedler, and L. T. Fan, A Combinatorial Approach for Generating Environmentally Benign Solvents and Separation Agents, presented at the ICheaP-6, Pisa, Italy, June 8-11, 2003.

Seo, H., S. Park, L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, Algorithmic Identification of Stoichiometrically Exact, Plausible Mechanisms of the Catalytic Combustion of Hydrogen on Platinum, presented at the AIChE Annual Meeting, Indianapolis, IN, U.S.A., November 3-8, 2002.

Seo, H., S. Park, L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, Graph-Theoretic Identification of Stoichiometrically Exact Mechanisms of the Catalytic Reduction of Nitrogen Dioxide (NO2) by Carbon Monoxide (CO) on Platinum Catalysts, presented at the AIChE Annual Meeting, Indianapolis, IN, U.S.A., November 3-8, 2002.

Romero, J., T. Holczinger, F. Friedler, and L. Puigjaner, Modelling the Scheduling of Common Intermediate Storage Multipurpose Batch Process Using a Graph Theoretical Approach, presented at the AIChE Annual Meeting, Indiana, U.S.A., November 7, 2002.

Shafie, S., L. T. Fan, B. Bertok, F. Friedler, H. Seo, and S. Park, Rapid Algorithmic Determination of Stoichiometrically Exact Mechanisms of the Catalytic Reactions: Illustration, presented at the ACS Midwest Regional Meeting, Lawrence, KS, U.S.A. , October 23-25, 2002.

Csertan, G., A. Pataricza, P. Harang, O. Doban, G. Biros, A. Dancsecz and F. Friedler, BPM Based Robust E-business Application Development (practical experience report) presented at the 4th European Dependable Computing Conference, EDCC-4, Toulouse, France, October 2002, also published in the proceedings of the Conference, 32-43.

Adonyi, R., J. Romero, L. Puigjaner, and F. Friedler, Incorporating Heat Integration in Batch Process Scheduling, presented at the PRES'02 (5th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 25-29, 2002.

Halasz, L., A. Nagy, M. Narodoslawsky, F. Friedler, Synthesis Method for Tankage Treatment, presented at the PRES'02 (5th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 25-29, 2002.

Novaki, S., B. Bertok, F. Friedler, and L. T. Fan, Algorithmic Synthesis of an Azeotropic-Distillation System: Production of Pure Ethanol Revisited, presented at the PRES'02 (5th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 25-29, 2002.

Ercsey, Z., Z. Kovacs, F. Friedler, and L. T. Fan, Super-Structure in Action, presented at the PRES'02 (5th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 25-29, 2002.

Fan, L. T., J. Liu, F. Friedler, and B. Bertok, Identification of Alternative Reaction Paths via Graph-theoretic Synthesis of Reaction Networks, presented at the AIChE Annual Meeting, Indianapolis, IN, U.S.A., November 3-8, 2002.

Fan, L. T., J. Liu, F. Friedler, and B. Bertok, Algorithmic Profit-potential Estimation for Developing Green Processes, presented at the AIChE Annual Meeting, Indianapolis, IN, U.S.A., November 3-8, 2002.

Holczinger, T., I. Heckl, A. C. Kokossis, and F. Friedler, Accelerated contextual optimization for scheduling large-scale HPC liquid factories, presented at the AIChE Annual Meeting, Reno, NV, U.S.A., November 4-9, 2001.

Strouvalis, A., I. Heckl, F. Friedler, and A. C. Kokossis, An Accelerated Branch and Bound Algorithm for Assignment Problems of Utility Systems, presented at the ESCAPE-11 (11th European Symposium on Computer Aided Process Engineering), Kolding, Denmark, May 27-30, 2001.

Suh, M.-H., F. Friedler, S. Park, and T.-Y. Lee, Retrofit Design of Chemical Processing Networks under Uncertainties: Application to Petrochemical Industry, presented at the ESCAPE-11 (Eleventh European Symposium on Computer Aided Process Engineering), Kolding, Denmark, May 27-30, 2001.

Bertok, B., F. Friedler, G. Feng, and L.T. Fan, Systematic Generation of the Optimal and Alternative Flowsheets for Azeotropic Distillation Systems, presented at the ESCAPE-11 (Eleventh European Symposium on Computer Aided Process Engineering), Kolding, Denmark, May 27-30, 2001.

Hertwig, T. A., A. B. Nagy, R. W. Pike, J. R. Hopper, and C. L.Yaws, An Advanced System for Optimizing the Design of a Chemical Production Complex, presented at the ESCAPE-11 (Eleventh European Symposium on Computer Aided Process Engineering), Kolding, Denmark, May 27-30, 2001.

Seo, H., D.-Y. Lee, S. Park, L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, Graph-Theoretical Identification of Pathways for Biochemical Reactions, presented at the PRES 2001 (4th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Florence, Italy, May 20-23, 2001.

Romero, J., F. Friedler, L. Puigjaner, Online Scheduling of Multipurpose Batch Process Considering Flexible Recipes, presented at the PRES 2001 (4th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Florence, Italy, May 20-23, 2001.

Hertwig, T. A., A. Xu, A. B. Nagy, R. W. Pike, J. R. Hopper, and C. L. Yaws, Optimal Configuration of Chemical Complexes Based on Economic, Environmental and Sustainable Costs, presented at the PRES 2001 (4th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Florence, Italy, May 20-23, 2001, also published in the proceedings of the conference, 1-6

Halasz, L., A. B. Nagy, T. Ivicz, F. Friedler, and L. T. Fan, Optimal Operation of the Steam Supply Network of a Complex Chemical Processing System, presented at the PRES 2001 (4th Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Florence, Italy, May 20-23, 2001, also published in the proceedings of the conference, 331-336

Seo, H., S. Park, L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, An Attempt for the Identification of Stoichiometrically Exact Mechanisms of the Catalytic Reduction of Nitrogen Dioxide (NO2) by Carbon Monoxide (CO) on Platinum Catalysts, presented at the KIChE 2001 Spring Meeting, Seoul, South Korea, April 27-28, 2001.

Polgar, B., S. Novaki, F. Friedler, and A. Pataricza, A Process Graph Based Representation of Syndrome Decoding Problem, presented at the IEEE DDECS 2001 (Design and Diagnostics of Electronic Circuits and Systems 2001), Gyor, Hungary, April 18-20, 2001.

Seo, H., S. Park, L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, Mechanism of Catalytic Combustion of Hydrogen, presented at the PSE Asia 2000 (International Symposium on Design, Operation and Control of Next Generation Chemical Plants), Kyoto, Japan, December 6-8, 2000.

Strouvalis, A., M., I. Heckl, F. Friedler, and A. C. Kokossis, Flexible Utility Networks for Maintenance and Operational Variations: A Customised Framework and an Accelerated Branch and Bound Algorithm, presented at the AIChE Annual Meeting, Los Angeles, CA, U.S.A., November 12-17, 2000.

Fan, L. T., S. Shafie, B. Bertok, and F. Friedler, Mechanism of HBr Formation Revisited, presented at the AIChE Annual Meeting, Los Angeles, CA, U.S.A., November 12-17, 2000.

Friedler, F., B. Bertok, L. T. Fan, and S. Shafie, Detailed Mechanism of Ammonia-Synthesis Reaction, presented at the AIChE Annual Meeting, Los Angeles, CA, U.S.A., November 12-17, 2000.

Bertok, B., F. Friedler, G. Feng, and L. T. Fan, Combinatorial Framework for the Algorithmic Synthesis of Azeotropic-Distillation Systems, presented at the AIChE Annual Meeting, Los Angeles, CA, U.S.A., November 12-17, 2000.

Seo, H., S. Park, L. T. Fan, S. Shafie, B. Bertok, and F. Friedler, An Attempt for the Identification of Stoichiometrically Exact Mechanisms of the Reaction between H2 and O2 on Platinum Catalysts, presented at the KIChE fall meeting, Pohang, South Korea, October 20-21, 2000.

Pike, R. W., T. A. Hertwig, and A. B. Nagy, An advanced system for optimizing the design of a chemical-production complex, presented at IFA Technical Conference, New Orleans, Louisiana, United States, October 1-4, 2000

Bertok, B., G. Feng, L. T. Fan, and F. Friedler, Combinatorial Framework for the Algorithmic Synthesis of Azeotropic-Distillation Systems, presented at the CHISA 2000 (14th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 27-31, 2000.

Bertok, B., R. Adonyi, G. Feng, L. T. Fan, and F. Friedler, Systematic Synthesis of an Azeotropic-Distillation System for Production of Pure Ethanol from its Aqueous Solution with Toluene as the Entrainer, presented at the CHISA 2000 (14th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 27-31, 2000.

Strouvalis, A., I. Heckl, F. Friedler, and A. C. Kokossis, Accelerated Branch and Bound Methods for Utility Network Optimisation, presented at the PRES 2000 (3rd Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Praha, Czech Republic, August 27-31, 2000.

Holczinger, T., L. Kalotai, and F. Friedler, Scheduling of Process Systems Comprising Continuous and Batch Operations, presented at the CHISA 2000 (14th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 27-31, 2000.

Nagy, A. B., G. Biros, F. Friedler, and L. T. Fan, Integrated Synthesis of Combined Process and Heat Exchanger Networks, presented at the CHISA 2000 (14th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 27-31, 2000.

Holczinger, T., L. Kalotai, and F. Friedler, Scheduling of Process Systems Comprising Continuous and Batch Operations, presented at the 20th Workshop on Chemical Engineering Mathematics, Veszprem, Hungary, July 26-29, 2000.

Nagy, A. B., F. Friedler, and L. T. Fan, Integrated Synthesis of Combined Process and Heat Exchanger Networks, presented at the 20th Workshop on Chemical Engineering Mathematics, Veszprem, Hungary, July 26-29, 2000.

Strouvalis, A., I. Heckl, F. Friedler, and A. Kokossis, Customized Solvers for the Operational Planning and Scheduling of Utility Systems, presented at the PSE 2000 (7th International Symposium on Process System Engineering), Keystone, CO, U.S.A., July, 16-21, 2000.

Feng, G., L. T. Fan, B. Bertok, L. Kalotai, and F. Friedler, A Graph-Theoretic Approach to the Algorithmic Synthesis of Azeotropic-Distillation Systems, presented at the AIChE Spring National Meeting, Atlanta, GA, U.S.A., March 5-9, 2000.

Strouvalis, A., I. Heckl, F. Friedler, and A. Kokossis, The Design of Intelligent Optimization Solvers for Utility Networks, presented at the AIChE Annual Meeting, Dallas, TX, U.S.A., October 31 - November 5, 1999.

Fan, L. T., B. Bertok, and F. Friedler, Combinatorial Framework for the Systematic Generation of Reaction Pathways, presented at the AIChE Annual Meeting, Dallas, TX, U.S.A., October 31 - November 5, 1999.

Strouvalis, A., I. Heckl, F. Friedler, and A. Kokossis, Intelligent Solvers for Utility Networks, presented at the AIChE Annual Meeting, Dallas, TX, U.S.A., October 31 - November 5, 1999.

Friedler, F., B. Imreh, and Z. Kovacs, Structural Analysis of Process Network Synthesis, presented at the INFORMS (Institute for Operations Research and the Management Sciences) Conference, Seattle, WA, U.S.A., October 25-28, 1998.

Friedler, F., Combinatorics in Chemical Engineering: Foundation, Applications, and Future Prospects, Plenary lecture, presented at the ESCAPE-9 (Ninth European Symposium on Computer Aided Process Engineering), Budapest, Hungary, May 31 - June 2, 1999.

Kovacs, Z., Z. Ercsey, F. Friedler, and L. T. Fan, Exact Super-Structure for the Synthesis of Separation-Networks with Multiple Feed-Streams and Sharp Separators, presented at the ESCAPE-9 (Ninth European Symposium on Computer Aided Process Engineering), Budapest, Hungary, May 31 - June 2, 1999.

Bertok, B., F. Friedler, and L. T. Fan, Generation of Process Synthesis Problems for Testing Evaluating and Comparing Synthesis Methods, presented at the PRES'99 (Second Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Budapest, Hungary, May 31 - June 2, 1999.

Feng, G., L. T. Fan, and F. Friedler, Synthesizing Alternative Sequences via a P-Graph Based Approach in Azeotropic Destillation Systems, presented at the PRES'99 (Second Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction), Budapest, Hungary, May 31 - June 2, 1999.

Nagy, A., L. Halasz, F. Friedler, and L. T. Fan, Integrated Synthesis of Process and Heat Exchanger Networks: Algorithmic Approach, presented at the PRES'99 (2nd Conference on Process Integration, Modelling and Optimisation for Energy Saving and Pollution Reduction, Budapest, Hungary, May 31 - June 2, 1999.

Ercsey, Z., Z. Kovacs, F. Friedler, and L. T. Fan, Separation-Network Synthesis: Global Optimum through Rigorous Super-Structure, presented at the AIChE Annual Meeting, Miami Beach, FL, U.S.A., November 15-20, 1998.

Nagy, A., F. Friedler, and L. T. Fan, Combinatorial Acceleration of Separable Concave Programming for Process Synthesis, presented at the AIChE Annual Meeting, Miami Beach, FL, U.S.A., November 15-20, 1998.

Fulop, J., F. Friedler, and A. Nagy, Integration of Combinatorial and Global Optimization Approaches for Solving Process Network Synthesis Problems, presented at the INFORMS (Institute for Operations Research and the Management Sciences) Conference, Seattle, WA, U.S.A., October 25-28, 1998.

Sanmarti, E., F. Friedler, and L. Puigjaner, Heat Integration in Chemical Multipurpose Batch Plants Using Schedule-Graph Representation, presented at the CHISA '98 (13th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 23-28, 1998.

Nagy, A., F. Friedler, and L. T. Fan, Algorithmic Generation of Multiple Solutions for Process Synthesis, presented at the CHISA '98 (13th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 23-28, 1998.

Kovacs, Z., Z. Ercsey, and F. Friedler, Retrofit Synthesis of Optimal Wastewater Treatment Systems, presented at the CHISA '98 (13th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 23-28, 1998.

Kalotai, L., A. Dallos, F. Friedler, and L. T Fan, Design of Environmentally Benign Chemical Species, presented at the CHISA '98 (13th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 23-28, 1998.

Holczinger, T., F. Friedler, and L. T. Fan, Process Synthesis for Retrofit Design, presented at the CHISA '98 (13th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 23-28, 1998.

Bertok, B., F. Friedler, and L. T. Fan, Random Generation of Test Problems for Process Synthesis, presented at the CHISA '98 (13th International Congress of Chemical and Process Engineering), Praha, Czech Republic, August 23-28, 1998.

Sanmarti, E., F. Friedler, and L. Puigjaner, Combinatorial Technique for Short Term Scheduling of Multipurpose Batch Plants Based on Schedule-Graph Representation, presented as keynote lecture at the ESCAPE-8 (Eighth European Symposium on Computer Aided Process Engineering), Brugge, Belgium, May 24-27, 1998.

Ercsey Z, Kovács Z. és Friedler F.: Szétválasztási hálózatok szintézise: globális optimum meghatározása szigorú szuperstruktúra alapján. 26. M{szaki Kémiai Napok, Veszprém, 1998. április 15-17.

Ercsey Z. és Kovács Z.: Szétválasztási hálózatok adott feladatosztályának algoritmikus megoldása. Veszprémi Informatikai Napok (VEIN'98), Veszprém, 1998. április 1-3.

Fan, L. T. and F. Friedler, Reaction Pathway Analysis by a Network Synthesis Technique, presented at the AIChE Annual Meeting, Los Angeles, CA, U.S.A., November 16-21, 1997.

Friedler, F., J. B. Varga, P. Hobor, and L. T. Fan, Combinatorial Approach to Process Synthesis: Sectionally Continuous Cost Functions of Operating Units, presented at the AIChE Annual Meeting, Los Angeles, CA, U.S.A., November 16-21, 1997.

Friedler, F., J. Fulop, and B. Imreh, Set Covering Approach to Process Network Synthesis, presented at the INFORMS (Institute for Operations Research and the Management Sciences), Dallas, TX, U.S.A., October 26-29, 1997.

Friedler, F., B. Imreh, and J. Fulop, Combinatorial Analysis of Process Network Synthesis, presented at the ISMP'97 (International Symposium on Mathematical Programming), EPFL, Lausanne, Switzerland, August 24-29, 1997.

Fulop, J., F. Friedler, and A. Nagy, A Global Optimization for Solving Process Network Synthesis Problems, presented at the ISMP'97 (International Symposium on Mathematical Programming), EPFL, Lausanne, Switzerland, August 24-29, 1997.

Ercsey Z. és Kovács Z.: Szétválasztási Hálózatok Szintézise: Lehetséges Struktúrák Generálása. 25. M{szaki Kémiai Napok, Veszprém, 1997. április 22-24.

Ercsey Z. és Kovács Z.: Szétválasztási Hálózatok Szintézise: Lehetséges Struktúrák Generálása. Veszprémi Informatikai Napok (VEIN'97), Veszprém, 1997. április 17-18.

Feng, G., F. Friedler, and L. T. Fan, Generating Alternative Sequences via a P-Graph Based Approach in Azeotropic Distillation Systems, presented at the AIChE National Meeting, Houston, TX, U.S.A., March 9-13, 1997.

Soptei, Cs. and F. Friedler, Water Minimization in a Nitrocellulose Industrial Process, presented at the AIChE National Meeting, Houston, TX, U.S.A., March 9-13, 1997.

Imreh, B., F. Friedler, and L. T. Fan, Effective Branch-and-Bound Strategy for Process Network Synthesis, presented at the INFORMS (Institute for Operations Research and the Management Sciences) Atlanta Fall 1996 Conference, Atlanta, GA, U.S.A., November 3-6, 1996.

Horvath, L., A. Petricsek, and F. Friedler, Combinatorial Approach to Heat Exchanger Network Synthesis, presented at the CHISA '96 (12th International Congress of Chemical Engineering), Praha, Czech Republic, August 25-30, 1996.

Feher, E., F. Friedler, and L. T. Fan, Accelerated Branch-and-Bound Method for Solving Process Network Synthesis Problems with Sectionally Continuous Cost Functions, presented at the XIII. International Conference on Mathematical Programming, Matraháza, Hungary, March 24-27, 1996.

Friedler, F., B. Imreh, and L. T. Fan, Satisfiability for the Structural Model of Process Network Synthesis, presented at the DIMACS (Center for Mathematics and Theoretical Computer Sciences) Workshop on Satisfiability Problem: Theory and Applications, Rutgers University, New Brunswick, NJ, U.S.A., March 11-13, 1996.

Kovacs, Z., F. Friedler, and L. T. Fan, Algorithmic Generation of the Mathematical Programming Model for Process Network Synthesis, presented at the IIIrd Workshop on Global Optimization, Szeged, Hungary, December 10-14, 1995, p. 60.

Imreh, B., F. Friedler, and L. T. Fan, Polynomial Algorithm for Improving the Bounding Procedure in Solving Process Network Synthesis by a Branch and Bound Method, presented at the IIIrd Workshop on Global Optimization, Szeged, Hungary, December 10-14, 1995, p. 27.

Kovacs, Z., F. Friedler, and L. T. Fan, Algorithmic Generation of the Mathematical Programming Model for Process Synthesis, presented at the AIChE Annual Meeting, Miami Beach, FL, U.S.A., November 12-17, 1995.

Friedler, F. and L. T. Fan, Combinatorial Foundation of Process Synthesis, Plenary Lecture at the 7th International Summer School of Chemical Engineering, Varna, Bulgaria, September 19-25, 1995.

Varga, J. B., F. Friedler, and L. T. Fan, Parallelization of the Accelerated Branch and Bound Algorithm of Process Synthesis: Application in Total Flowsheet Synthesis, presented at the ESCAPE-5 (Fifth European Symposium on Computer Aided Process Engineering), Bled, Slovenia, June 11-14, 1995.

Hangos, K. M., J. B. Varga, F. Friedler, and L. T. Fan, Integrated Synthesis of a Process and its Fault-Tolerant Control System, presented at the ESCAPE-5 (Fifth European Symposium on Computer Aided Process Engineering), Bled, Slovenia, June 11-14, 1995.

Kovacs, Z., F. Friedler, and L. T. Fan, Parametric Study of Separation Network Synthesis: Extreme Properties of Optimal Structures, presented at the ESCAPE-5 (Fifth European Symposium on Computer Aided Process Engineering), Bled, Slovenia, June 11-14, 1995.

Varga, J. B., F. Friedler, Y. Zhang, and L. T. Fan, Synthesis of Reaction Paths with Minimum Involvement of Hazardous Substances, presented at the 10th Anniversary Conference on Hazardous Waste Research, Kansas State University, Manhattan, KS, U.S.A., May 23-24, 1995.

Friedler, F., J. B. Varga, E. Feher, and L. T. Fan, Combinatorially Accelerated Branch-and-Bound Method for Solving the MIP Model of Process Network Synthesis, presented at the International Conference on State of the Art in Global Optimization: Computational Methods and Applications, Princeton University, Princeton, NJ, U.S.A., April 28-30, 1995.

Varga, J. B., F. Friedler, and L. T. Fan, Risk Reduction through Waste Minimizing Process Synthesis, presented at the 21st Annual RREL (Risk Reduction Engineering Laboratory) Research Symposium, Cincinnati, OH, U.S.A., April 4-6, 1995; also published in the Proceedings of the Symposium, 359-363.

Kovacs, Z., F. Friedler, and L. T. Fan, A New Formulation for Solving Separation Network Synthesis Problems of Multiple Feed-Streams and Multicomponent Product Streams, presented at the AIChE National Meeting, Houston, TX, U.S.A., March 19-23, 1995.

Friedler, F., J. B. Varga, and L. T. Fan, Integration of Waste Treatment into Process Synthesis, presented at the AIChE National Meeting, Houston, TX, U.S.A., March 19-23, 1995.

Varga, J. B., F. Friedler, and L. T. Fan, Parallel Combinatorially Accelerated Branch and Bound Algorithm for Process Synthesis, presented at the AIChE Annual Meeting, San Francisco, CA, U.S.A., November 13-18, 1994.

Friedler, F. and L. T. Fan, Algorithmic Generation of a Minimally Complex Mixed-Integer Programming Model for Process Synthesis, presented at the AIChE Annual Meeting, San Francisco, CA, U.S.A., November 13-18, 1994.

Friedler, F., J. B. Varga, and L. T. Fan, Algorithmic Approach to the Integration of Total Flowsheet Synthesis and Waste Minimization, presented at the AIChE Summer National Meeting, Denver, CO, U.S.A., August 14-17, 1994.

Friedler, F., J. B. Varga, and L. T. Fan, Decision-Mapping for Design and Synthesis of Chemical Processes: Application to Reactor-Network Synthesis, presented at the FOCAPD '94 (Fourth International Conference on Foundations of Computer-Aided Process Design), Snowmass Village, CO, U.S.A., July 10-14, 1994.

Hangos, K. M., F. Friedler, J. Varga, and L. T. Fan, Graph-Theoretic Approach to Integrated Process and Control System Synthesis, presented at the IFAC '94 (International Federation of Automatic Control) Workshop on Integration of Process Design and Control, Baltimore, MD, U.S.A., June 27-28, 1994; also published in the Proceedings of the Workshop, 58-63.

Varga, J. B., F. Friedler, and L. T. Fan, Systematic Approach for Process Synthesis Incorporating In-Plant Waste Treatment, presented at the Conference on Hazardous Waste Remediation, Bozeman, MT, U.S.A., June 8-10, 1994.

Friedler, F. and L. T. Fan, Reduction of Subproblem Size for the Accelerated Branch and Bound Algorithm of Process Network Synthesis, presented at the XII. International Conference on Mathematical Programming, Matrafured, Hungary, January 22-27, 1994.

Kovacs, Z., F. Friedler, and L. T. Fan, Fundamental Properties of Optimal Separation Networks, presented at the AIChE Annual Meeting, St. Louis, MO, U.S.A., November 7-12, 1993.

Varga, J., F. Friedler, and L. T. Fan, Combinatorial Technique for Multiperiod Process Network Synthesis, presented at the 21st Hungarian Conference on Operations Research, Szeged, Hungary, October 2-4, 1993.

Kovacs, Z., F. Friedler, and L. T. Fan, Algorithmic Generation of the NLP Model for Separation Network Synthesis, presented at the 21st Hungarian Conference on Operations Research, Szeged, Hungary, October 2-4, 1993.

Friedler, F., L. T. Fan, and B. Imreh, Maximal Structure Generation in Process Network Synthesis, presented at the 21st Hungarian Conference on Operations Research, Szeged, Hungary, October 2-4, 1993.

Friedler, F. and L. T. Fan, Reduction of Subproblem Size for the Combinatorially Accelerated Branch and Bound Algorithm of Process Network Synthesis, presented at the 21st Hungarian Conference on Operations Research, Szeged, Hungary, October 2-4, 1993.

Friedler, F. and L. T. Fan, Combinatorial Technique for the Design and Synthesis of Large Scale Manufacturing Systems, presented at the IFAC '93 (12th World Congress, International Federation of Automatic Control), Sydney, Australia, July 19-23, 1993; also published in the Proceedings of the Congress, 10, 397-400.

Friedler, F., J. Varga, and L. T. Fan, A Combinatorial Approach to the Multiperiod Synthesis of the Structure of Process Industries, presented at the ESCAPE-3 (European Symposium on Computer Aided Process Engineering), Graz, Austria, July 5-7, 1993; also published in the Proceedings of the Symposium, 2-6

Kovacs, Z., F. Friedler, and L. T. Fan, Algorithmic Generation of the Mathematical Model for Separation Network Synthesis, presented at the ESCAPE-3 (European Symposium on Computer Aided Process Engineering), Graz, Austria, July 5-7, 1993; also published in the Proceedings of the Symposium, 7-11

Kovacs, Z., F. Friedler, and L. T. Fan, Redundancy in Separation Networks for Waste Elimination, presented at the Conference on Hazardous Waste Research, Manhattan, KS, U.S.A., May 25-26, 1993.

Friedler, F., J. Varga, and L. T. Fan, A Combinatorial Technique for Determining the Optimal Development Strategy for the Chemical and Petroleum Industries, presented at the AIChE National Meeting, Houston, TX, U.S.A., March 28-April 1, 1993.

Friedler, F. and L. T. Fan, Reduction of Subproblem Size for the Accelerated Branch and Bound Method of Process Synthesis, presented at the AIChE National Meeting, Houston, TX, U.S.A., March 28-April 1, 1993.

Friedler, F. and L. T. Fan, Combinatorial Acceleration of the Branch and Bound Search for Process Network Synthesis, presented at the Symposium on Applied Mathematical Programming and Modeling, Budapest, Hungary, January 6-8, 1993; also published in the Proceedings of the Symposium, 192-200.

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Combinatorial Technique for Process Design and Synthesis, presented at the AIChE Annual Meeting, Miami, FL, U.S.A., November 1-6, 1992.

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Combinatorial Foundation of Process Synthesis, presented at the 42nd CSChE (Canadian Society for Chemical Engineering) Annual Conference, Toronto, Canada, October 18-21, 1992; also published in the Proceedings of the Conference, 207-208.

Friedler, F. and L. T. Fan, Process Synthesis Incorporating In-Plant Waste Treatment: Algorithmic Approach, presented at the ACS Special Symposium on Hazardous-Waste Management, Atlanta, GA, U.S.A., September 21-23, 1992; also published in the Proceedings of the Symposium, I, 325-328.

Friedler, F., Z. Kovacs, and L. T. Fan, Unique Separation Networks for Improved Waste Elimination, presented at the ACS Special Symposium on Hazardous-Waste Management, Atlanta, GA, U.S.A., September 21-23, 1992; also published in the Proceedings of the Symposium, II, 457-460.

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Combinatorial Structure of Process Network Synthesis, presented at the Sixth SIAM Conference on Discrete Mathematics, Vancouver, Canada, June 8-11, 1992.

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Computer-Aided Waste Minimizing Design of a Chemical Process, presented at the Seventh Annual Conference on Hazardous Waste Research, Boulder, CO, U.S.A., June 1-2, 1992; also published in the Proceedings of the Conference, 107-116.

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Combinatorial Algorithms for Process Synthesis, presented at the ESCAPE-1 (European Symposium on Computer Aided Process Engineering), Elsinore, Denmark, May 24-28, 1992.

Narodoslawsky, M., F. Friedler, L. Kiraly, and H. J. Altenburger, SIMBIOS - A New Simulation Program for Biotechnology with Novel Design, presented at the Workshop on Bioprocess Simulation in Practice, Graz, Austria, April 14, 1992.

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Accelerated Branch and Bound Method for Process Network Synthesis, Preprints of the Department of Mathematics, University of Veszprem, Hungary, 3/5, 1-7 (1992).

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, A Systematic Approach to Waste Minimizing Synthesis of a Chemical Process: Production of Perchloromethyl Mercaptan, presented at the AIChE National Meeting, Pittsburgh, PA, U.S.A., August 17-21, 1991; also published in the Proceedings of the Conference, 93-98.

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, An Accelerated Branch and Bound Method for Process Synthesis, presented at the Fourth World Congress of Chemical Engineering, Karlsruhe, Germany, June 16-21, 1991; also published in the Proceedings of the Congress, paper 12.2-9.

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Process Synthesis by Exploiting the Combinatorial Properties of Feasible Process Structures, presented at the Fourth World Congress of Chemical Engineering, Karlsruhe, Germany, June 16-21, 1991; also published in the Proceedings of the Congress, paper 12.2-5.

Friedler, F., K. Tarjan, Y. W. Huang, and L. T. Fan, Waste Minimizing Synthesis of a Process for Production of Perchloromethyl Mercaptan: Systematic Approach, presented at the Conference on Hazardous Waste Research, Kansas State University, Manhattan, KS, U.S.A., May 29-30, 1991; also published in the Proceedings of the Conference, 248-261.

University of Pannónia, Veszprém	Green Source Holding LLC, Austin, USA	Budapest University of Technology and Economics, Hungary	University of Szeged, Hungary
Pázmány Péter Catholic University, Hungary	University of Nottingham, Malaysia	Graz University of Technology, Austria	Autonomous University of Bucaramanga, Columbia
Chemical Engineering at National Cheg Kung University, Taiwan	De La Salle University, Manila, Philippines	De La Salle University, Manila, Philippines	Kansas State University, Manhattan, Kansas, U.S.A.
The University of Manchester Institute of Science and Technology, Manchester, United Kingdom	Universitat Politecnica de Catalunya, Barcelona, Spain